2009年10月29日

The inside story on place cells

Neurons known as place cells encode spatial information that is needed to guide an animal's movement.

Nearly 40 years after these cells were discovered, neuroscience gets a look at their internal dynamics.


On page 941 (see page of this issue, Haevey et al.(Harvey,c.d.,Collman,F.,Do,bec,D.A.&Tank,D.W. Nature 461,941-946/2009) deecribe a novel combination of techniques that they have used to address unresolved questions about brain function.

The experiments involve mice navigating within a virtual-reality setting while intracellular electrophysiological recordingsare made of particular neurons ― pyramidal neurons ― in the hippocampus.

The ability to gather such data adds greatly to the information thatcan be glened from the accompanying extracellular recordings.


### DataBace ###
nature Vol.461 837-1018 Issue no.7266 15 Octiber 2009
Article p.941 / Intracellular dynamics of hippocampal place cells during virtual navigation / C D Harvey et al. (Princeton University)
News and Views p.889 / Neuro Science : The insade story on place cells / Douglas Niz


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2009年02月26日

Neuromotor prosthics

Brain-machine interfaces are a promising approach for treating parelysis due to spinal cord injury, by reroutting control signals from the brain to the muscles. Previous work showed that monkeys can be traibed to move robotic arms using signals from electrodes inplated in the brain.

Now it is reported that monkeys can learn move a temporariky paralysed wrist using signals artificially routed from single neurons in the brain that had not previously been associated with that movement. This may have significant implications for future design of blain-machine interfaces, which have tradidionally relied on the activity of dedecated populations of nurons.

### DataBace ###
nature Vol.456 545-674 Issue no.7222 4 December 2008
Letter p.639/Direct control of paralysed muscles by cortical neurons/ C T Moritz et al. (University of Washington)


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