2009年10月24日

Prion disease transmission

Chonic wasting disease (CWD) is a highly contagious prion disease that causes neurodegeneration in several species in the deer family, including the elk and moose.

The precise mechanisms of natureal CWD transmission are unresolved.

IT is known that once an animal shows signs of the disease, its excretions can contain contagious prions.

Stanley Prusiner and colleagues show that mule deer in infected with CWD begin to excrete in fectious prions in faeces long before they develop visible signs of the disease.

This suggests a plausible, natural mechanism that could explain the high incidence and efficient horizontal transmission of CWD among deer - and may also be relevant for the similarly contagious scrapie in sheep.


### DataBace ###
nature Vol.461 439-558 Issue no.7263 24 September 2009
Letter p.529 / Asymptomatic deer excrete infectious prions / G. Tamguney et al. (University of California, San Francisco)

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